New option added for Vitamin B supplements (including folate). New evidence; conclusion changed for Type of carotid endarterectomy. New evidence; conclusion confirmed for Blood pressure reduction, Cholesterol reduction, Alternatives to aspirin, Different blood pressure-lowering regimens, Aspirin dose, Anticoagulation (sinus rhythm), Carotid endarterectomy (less than 30% stenosis), Carotid endarterectomy in people with moderate (30–49%) symptomatic carotid artery stenosis, Carotid endarterectomy (50–69% stenosis), Carotid endarterectomy (more than 70% stenosis), Carotid endarterectomy (near occlusion), Carotid angioplasty , Carotid angioplasty plus stenting, Anticoagulant treatment: AF and previous stroke or TIA and Antiplatelets: AF and previous stroke or TIA.

New evidence; conclusion confirmed for Adjuvant chemotherapy.

New evidence; conclusion changed for Renal replacement therapy (prophylactic haemofiltration/dialysis). New evidence; conclusion confirmed for Sodium chloride-based fluids, N-Acetylcysteine, Contrast media (iso-osmolar), Fenoldopam, Calcium channel blockers, Loop diuretics, Renal replacement therapy (high-dose continuous), Renal replacement therapy and Loop diuretics.

New evidence; conclusions confirmed for CBT and Dietary supplements.

New condition. New options added for Single- or multiple-session brief intervention in primary care, Universal screening plus brief intervention in primary care, Targeted screening plus brief intervention in primary care, Single- or multiple-session brief intervention in emergency departments, Universal screening plus brief intervention in emergency departments and Targeted screening plus brief intervention in emergency departments.

New evidence; conclusions confirmed for Interferon alfa plus cytotoxic chemotherapy and Interferon alfa plus interleukin-2 plus chemotherapy.

New evidence; conclusion confirmed for Permethrin (topical), Lindane (topical), Crotamiton (topical), Benzyl benzoate (topical), Malathion (topical), Sulphur compounds (topical) and Ivermectin (oral).

New evidence; conclusions confirmed for Manual (large or small) incision extracapsular extraction and Phaco extracapsular extraction.

New evidence; conclusion confirmed for Antiplatelet drugs, Calcium supplementation, Antioxidants, Marine oil (fish oil) and other prostaglandin precursors (evening primrose oil), Antihypertensive agents, Prophylactic anticonvulsants, Antihypertensives, Interventionist care for severe early-onset pre-eclampsia, Plasma expanders and Anticonvulsants for eclampsia.

New evidence; conclusions changed for Acupuncture and Early normal activity. New evidence; conclusion confirmed for Exercise for non-specific neck pain, Traction, Mobilisation, Manipulation, Collars and pillows, Mobilisation (early) for acute whiplash injury, Physical treatments and Drug treatments for neck pain with radiculopathy.

New options added for Fusion inhibitors and CCR5 inhibitors. New evidence; conclusion confirmed for PEP in healthcare workers, Boosted PI-based regimens, NNRTI-based triple regimens, Standard PI based triple regimens and Early v delayed treatment.

New condition. New options added for Morphine, Codeine, Dihydrocodeine, Fentanyl (transdermal), Hydromorphone, Methadone, Oxycodone and Tramadol.

New evidence; conclusion changed for Education. New evidence; conclusion confirmed for Different frequencies of insulin administration (CSII v MDI).

New evidence; conclusion confirmed for Aciclovir (oral) for 1 year to prevent recurrence.

New evidence; conclusion changed for Oxygen by non-re-breather mask.

New search performed and critically appraised; no new evidence selected for inclusion.

New option added for Analgesics. New evidence; conclusion confirmed for Expectorants.

New evidence; conclusion changed for Antibiotics.

New option added for Oestrogen (topical) in postmenopausal women. New evidence; conclusion confirmed for Continuous prophylaxis.

New evidence; conclusion confirmed for Open mesh repair, TEP laparoscopic repair, TAPP laparoscopic repair, Open suture repair, Expectant management, Open mesh repair, Open mesh repair and TAPP laparoscopic repair.

New search performed and critically appraised; no new evidence selected for inclusion.

New evidence; conclusions confirmed for Antibacterials (topical; with or without corticosteroids) and Acetic acid (topical) for treating otitis externa.

New search performed and critically appraised; no new evidence selected for inclusion.

New evidence; conclusion changed for Motility stimulants. New evidence; conclusion confirmed for Lifestyle advice/modification, H2 receptor antagonists, Proton pump inhibitors, Proton pump inhibitors, Open surgery and Laparoscopy.

New evidence; conclusions changed for Topiramate and Pharmacotherapy plus psychotherapy. New evidence; conclusion confirmed for CBT-BN, CBT-ERP, Pure self-help CBT and SSRIs.